In the News
The Martin lab studies the enzyme used by thousands of researches for synthesizing RNA in the test tube. New work published in the journal Nucleic Acids Research (and highlighted as a “Breakthrough Article”) characterizes undesired (and at times, technology-limiting) impurities in that synthesis, providing a mechanistic understanding that will help the design of solutions. The work exploits a modern tool in genomics, RNA-Seq, but applies it in new ways. While gel electrophoresis has been the tool of choice for the past century, this new approach represents a huge advance, identifying not just lengths of RNA, but exact sequences and sequence distributions.
RNA therapeutics companies are already taking notice, particularly those invested in mRNA therapeutics, since chemical synthesis of long RNAs is not a possibility. Impurities in the RNA trigger a potentially lethal immune response, and have been holding back major advances in what could be a key, new therapeutic approach, with wide applicability. This work does not provide the solution, but provides key understandings that may well lead to solutions.
Jianhan Chen recently received a four-year, $600,000 grant from the National Science Foundation to study a newly recognized class of proteins with highly flexible three-dimensional (3D) structural properties, in particular some extra-floppy ones called intrinsically disordered proteins (IDPs).
Proteins are macromolecules that control nearly all aspects of cell function from response to external stimuli to control of cell cycle and cell fate decisions, Chen explains. He adds that IDPs are unusual because while most proteins adopt stable 3D structures to do their work in the cell, IDPs instead remain structurally disordered, that is, extremely flexible. They are believed to account for about one-third of all eukaryotic proteins and are key components of cellular signaling and regulatory networks.
Scientists now believe that by staying flexible, IDPs have an advantage in interacting with other proteins and each other, perhaps because the floppy state lets them respond faster than a more rigid structure, or lets them interact with a wider variety of molecules, or both, Chen says.
Jeanne Hardy, associate professor of chemistry, whose research focuses on a key protein linked to neurological disorders such as Alzheimer’s disease, is being recognized with the inaugural Mahoney Life Sciences Prize at the University of Massachusetts Amherst. A panel of expert judges from the life sciences sector observed that the “biomedical implications are significant” and “this could turn out to be one of ‘the’ pivotal studies in the effort to combat Alzheimer’s.” Hardy will receive the prize and present her research with life sciences experts and UMass officials and scientists at a breakfast ceremony on June 19 at the UMass Club in Boston. “Professor Hardy’s research rose to the top of three highly competitive rounds of review,” said Tricia Serio, dean of the College of Natural Sciences. “Her work exemplifies the outstanding translational research for which our faculty are well known.”
Chemist Vincent Rotello and colleagues at University College London (UCL), U.K., announce that they have developed a “quick and robust” blood test that can detect liver damage before symptoms appear, offering what they hope is a significant advance in early detection of liver disease. Details appear in Advanced Materials.
Their new method can detect liver fibrosis, the first stage of liver scarring that can lead to fatal disease if left unchecked, from a blood sample in 30-45 minutes, the authors note. They point out that liver disease is a leading cause of premature mortality in the United States and U.K., and is rising. It often goes unnoticed until late stages of the disease when the damage is irreversible.
For this work, Rotello and his team at UMass Amherst’s Institute of Applied Life Sciences (IALS) designed a sensor that uses polymers coated with fluorescent dyes that bind to blood proteins based on their chemical processes. The dyes change in brightness and color, offering a different signature or blood protein pattern.
Research institutions still have a long way to go in retaining women in STEM fields, and particularly in the physical sciences, says Sankaran “Thai” Thayumanavan, but this month his chemistry lab celebrated a success as he escorted six women (Celia Homyak, Youngju Bae, Mallory “Molly” Gordon, Priyaa Prasad, and Poornima Rangadurai) receiving their advanced degrees at Graduate Commencement on May 11. He says, “It didn’t dawn on me until we were there at the ceremony, but suddenly I realized ‘Wow!’ We have done something really amazing here. I hooded six women scientists that day, and they have all gone on to find good positions in the physical sciences. That doesn’t happen very often.”
Christie L.C. Ellis, a fourth-year doctoral candidate in chemistry and an advisee of Dhandapani “DV” Venkataraman, whose research focuses on materials used in solar cells, has received a coveted Mass Media Fellowship from the American Association for the Advancement of Science (AAAS). It will send her to work as a science writer at the St. Louis Post-Dispatch for a 10-week internship beginning in June.
Among other benefits, the long-running program will provide Ellis with travel funds, an orientation at AAAS in Washington, D.C., a stipend and training in interviewing skills and news judgment. She expects to shadow a science writer at the newspaper for a short time and then work on her own stories. “I feel really fortunate to have this fellowship. They’re giving me a really great opportunity and investing a lot in me,” she says.
Her advisor says, “Christie is passionate about communicating science to a broad audience. Therefore, this prestigious fellowship will provide a fantastic opportunity for her to learn from experts in the media industry and closely interact with them. We are eager to learn from Christie’s experience and improve our science communication skills.”
Professor Paul Dubin passed away May 22, 2018.
His research interest was polyelectrolytes and long-chain molecules in which every repeat unit carries a charge, with focus on their interaction with oppositely charged molecules such as surfactant micelles, nanoparticles and proteins, with the objective of fundamental understanding of solution behavior.
In an unexpected finding, chemist Sankaran “Thai” Thayumanavan and colleagues at the University of Massachusetts Amherst show for the first time how movement of a single chemical bond can compromise a membrane made up of more than 500 chemical bonds. Their system uses light as a switch to create a reversible, on-demand molecular control mechanism.
Thayumanavan explains, “There are many applications that one can imagine developing from these fundamental findings, especially ones that need controlled release. For example, we have shown that two compounds that would readily react with each other can be in the same solution but are separated by a very thin membrane made of a few nanometers and therefore do not react with each other.”
“But upon exposure to light, the membrane gets compromised to allow the two components to react with each other,” he adds. “The interesting thing is that the membrane is not permanently compromised upon exposure to light, but only when the light is on.”
His postdoctoral associate Mijanur Rahaman Molla and doctoral student Poornima Rangadurai conducted most of the experimental work. The UMass Amherst group also collaborated with theoretical chemists Lucas Antony and Juan de Pablo at the University of Chicago, who modeled the system in order to more deeply understand it, Thayumanavan notes. Details are online now in Nature Chemistry.
Elvan Cavac wins the Grinspoon Entrepreneurial Spirit Award for Pickmeup Snacks
Elvan Cavac, from the Martin Group, won the Grinspoon Entrepreneurial Spirit Award for her start-up, Pickmeup Snacks, which uses cricket protein to create healthy and sustainable treats.
Cavac states, "Pickmeup Snacks are nutrient dense, high protein snacks made with cricket protein powder. We currently have two flavors: cheese cracker crusher and chocolate chip cookie beast. One serving gives you about 200 calories, and 10 grams of protein. They are also really delicious. If you would like to check us out, visit our website and join our newsletter! https://www.pickmeupsnacks.com/
"Why bugs? Our mission statement at Pickmeup Snacks is to lead the change in the western diet for a healthier and sustainable future. Livestock industry generates more greenhouse gas emissions than transport and it takes about 2000 gallons of water to produce only one pound of beef. The world is projected to host 9 billion people in 2050. We simply cannot keep feeding the livestock industry like we do right now if we want to live in a sustainable future. The way we think about food needs to change.
"Our vision is that bugs will be a staple in our kitchens, and we will eat more of them than beef or pork. This is due to their excellent nutrition and sustainable production profiles. For example, compared with cattle, crickets need 6x less feed, 0.045% as much water and produce 80% less methane. In the mean time, while a sirloin steak is only 29% protein, dried crickets are about 70% protein.
"My experience with Berthiaume Center for Entrepreneurship has been amazing. Their support and guidance helped me turn this business into reality. In addition to having created this business, I have gained tremendous strategic planning and leadership skills. I am really grateful and I will continue working there to get my start-up to grow bigger!"
A new program created with a gift from University of Massachusetts Amherst alumnus William “Bill” A. Lee, executive vice president of research at Gilead Sciences, will broaden opportunities for underrepresented and first-generation UMass Amherst students who aspire to be scientists.
The new William Lee Science Impact Program (Lee-SIP) at the College of Natural Sciences gives selected undergraduates the opportunity to work with faculty on a wide range of research projects. Currently, 13.4 percent of the college’s 6,067 undergraduates are from underrepresented groups, and 29 percent are first-generation college students.
Lee, who earned a B.S. in chemistry from UMass Amherst in 1977, was the first in his family to graduate from college, where he developed an understanding of the impact research can have on both students and society. “When Dr. Marvin Rausch asked me if I was interested in working in his lab over the summer, I had no idea of what to expect or how it would change my course in life. I thrived on the comradery with grad students and postdocs in the lab and for the first time, science left the text book and became alive.”
Phytos Therapeutics, headed by Ryan Landis (PhD student in the Rotello group), won $20,000 in the Innovation Challenge, hosted by the Berthiaume Center for Entrepreneurship. Phytos Therapeutics designs, develops and licenses groundbreaking nanotechnology to address the growing dangers of infectious disease.
On Thursday, April 5, the Berthiaume Center for Entrepreneurship awarded $65,000 to three ventures at Innovation Challenge: The Final. Seven student-led ventures pitched to a panel of seven VIP judges. Alexander Smith’s eBiologics won $30,000. Ryan Landis’ Phytos Therapeutics won $20,000. KINASE, Inc. was awarded $15,000.
Landis adds, "The entire process has been humbling and I have been truly enlightened from the experience. I am very grateful to many graduate, professor, and staff members in the UMass Amherst Chemistry Department, the Berthiaume Center for Entrepreneurship, the Isenberg School of Management, the UMass Institute for Applied Life Sciences, and the Stockbridge School of Agriculture. Without their advice, insight, and connections, I would not be where I am today."
Christie Ellis wins CNS Excellence in Diversity & Inclusion Award
The CNS Excellence in Diversity and Inclusion Awards recognize and honor excellence and achievement in promoting a climate of diversity and inclusion within the college. Christie Ellis demonstrated leadership and innovation in increasing, retaining, and supporting the success of individuals who have been historically underrepresented in CNS and/or in removing the barriers that prevent full participation of all members of our community.