Biomolecular Structure - Chemistry 791A Fall 2003
The overall goal of this course is to understand macromolecular structures in biology. Traditional lectures will present concepts in structure, including the physical basis for structure and stability, molecular interactions, and design. We will also have computer workshops using Protein Explorer and other public domain software for manipulating macromolecules in three dimensions. Finally, each student will present an oral presentation taking the class on a WEB-based tour of the structure of a chosen biomolecule, illustrating principles learned throughout the course, and relating them to the biological function.
Instructor: Lynmarie Thompson (thompson@chem.umass.edu, 5-0827, LGRT 403E)
Meetings: Tu/Thu 9:30-10:45 in LGRT 202 or Chemistry Resource Center (CRC)
Text: Introduction to Protein Structure (2nd ed), by Carl Branden & John Tooze,
plus selected readings from other sources including
Proteins: Structures and Molecular Properties, by T. Creighton
Crystallography Made Crystal Clear, by Gale Rhodes
Grading: 50% (25% each) for 2 take-home exams (to be completed independently -- NO DISCUSSIONS)
25% for class participation & homework, 25% for final presentation
Prerequisites: Introductory Biochemistry, Sophomore Organic Chemistry
Introductions = Homework #1
Please send me an email message by next Monday 9/8 which includes the following:
Name, major, year in program, & research group
Background/experience - biochemistry courses taken, computer experience looking at protein structures
Interests -- what topics you'd like to see in this course (other software?)