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NEWS March 2008 ·
The group has received funding
from the National Science Foundation to develop mass spectrometry-based methods to study macromolecular conformations
and interactions in biophysics and nanotechnology January 2008 ·
Adriana Zeledon rejoined the group after several
months at Biogen IDEC to complete her Master’s thesis work on disulfide
scrambling and its influence on protein conformation ·
Two undergraduate students joined the group to
participate in research on CRABP-RAR interaction (Charles Beyrouthy) and
behavior of protein-polymer conjugates (Jamal Salah) December 2007 ·
The Christmas Party was attended this year not
only by the current group members, but also by two of our alums (Dr. Ben
Mohimen and Dr. Joshua Hoerner of Schering-Plough Research Institute). Click
here to see the photos from the Party (password
protected) ·
The group has received funding from a
biopharmaceutical company Biogen IDEC
(NYSE: BIIB) for developing experimental methodology to probe stability of
protein drugs November 2007 ·
Rachael Leverence successfully defended Ph.D.
dissertation “Elucidating the Interaction between Human Serum Transferrin
Transferrin Receptor using Electrospray Ionization Mass Spectrometry” and
moved to the University of Wisconsin Madison August 2007 ·
A paper published in Analytical Chemistry as an
accelerated article (R.R. Abzalimov,
P.L. Dubin and I.A. Kaltashov. Glycosaminoglycans
as naturally occurring combinatorial libraries: developing a mass
spectrometry-based strategy for characterization of anti-thrombin interaction
with low molecular weight heparin and heparin oligomers. Anal. Chem. 2007, 79, in 6055-6063) was featured on the
journal cover June 2007 ·
Four
former group members attended the annual “Alumni Breakfast” at the ASMS
Conference: Dr. Dmitry R. Gumerov of Bruker Daltonics (PhD’2003), Prof. Hui
Xiao of Albert Einstein School of Medicine (PhD’2004), Dr. Wendell P.
Griffith of Johns Hopkins Medical School (PhD’2005) and Dr. Mingxuan
“Sunshine” Zhang of Schering-Plough Research Institute (PhD’2007). ·
Four
posters and one oral presentation were presented by our group members at the 55-th
annual ASMS Conference on Mass Spectrometry and Allied Topics (Indianapolis,
IN): MP490
“Modulation
of transferrin conformation by metal binding studied by hydrogen exchange and
mass spectrometry”
(M. Zhang, A.B. Mason and I.A. Kaltashov) MP498
“Interaction of the Cellular Retinoic Acid Binding Protein with the Retinoic
Acid Receptor: A Mass Spectrometric Study” (V. Sjoelung and I.A.
Kaltashov) TP335
“ESI MS study of pepsin inactivation: implications of small-scale protein
conformational changes for substrate binding and enzymatic activity” (A.K. Frimpong and I.A. Kaltashov) WOC310 “Conformation-specific characterization of protein
higher order structure using hydrogen exchange and tandem mass spectrometry” (R.R. Abzalimov and I.A. Kaltashov) ThP279 “Heparin-protein binding: an interaction model
emerging from a combinatorial approach”
(R.R. Abzalimov; P.L. Dubin and I.A. Kaltashov) April 2007 ·
Dr. Cedric Bobst
(PhD’2004, Ohio State University) became our newest group member. He will be
using HDX MS to probe molecular mechanism of iron transport and delivery to
tissue via the transferrin cycle ·
Our
former group member Dr.
Hui Xiao (PhD’2004) was promoted to a tenure-track faculty position (in
the rank of Assistant Professor) at the Department of Pathology, Albert
Einstein School of Medicine (Bronx, NY) March 2007 ·
Our
former group member Dr.
Wendell P. Griffih (PhD’2005) accepted a tenure-track faculty position
(in the rank of Assistant Professor) at the Department of Chemistry,
University of Toledo (Toledo, OH) January 2007 ·
Dr.
Mingxuan “Sunshine” Zhang left our group to become a Research Scientist at Schering-Plough
Research Institute’s new facility in Boston |