About Us

We are a Biological Mass Spectrometry group at the University of Massachusetts Amherst. Our research is focused on developing mass spectrometry-based strategies to study protein architecture, dynamics, and interactions with small molecules and other biopolymers.

 

Contact Our Lab

 

Mailing Address:

University of Masschusetts Department of Chemistry

710 North Pleasant Street, LGRT #104

Amherst, MA 01003

Telephone:

Lab: 413.545.4888
Professor Kaltashov's Office: 413.545.1460

Email:

Kaltashov@chem.umass.edu

 

 

Our laboratory is located in the Life Science Labortories Building, Third Floor, on 240 Thatcher Lane.


Recent News

 

Aug 2014

Congratulations to Khaja Muneeruddin on receiving 2014-2015 Global Fellowship Award from the United States Pharmacopeial Convention (USP) for the development of novel analytical tools to characterize heterogeneity in biopharmaceutics

 

Congratulations Ololade Fatunmbi for recieving 3 travel awards this year to present her research: National Science Foundation Travel Award for the annual Research in Computational Molecular Biology Conference, the Federation of American Societies for Experimental Biology MARC Travel Award for the annual Intelligent Systems in Molecular Biology Conference, and the Advancing Science Travel Award for the Annual NOBCChE Conference

 

June 2014

Lab members Son Nguyen, Hanwei Zhao, Khaja Muneeruddin, Shengsheng Xu, and Jake Pawlowski traveled to Baltimore, Maryland to attend the annual conference of the American Society for Mass Spectrometry and present their research

 

June 2012
Several group members went to Shire Human Genetic Therapies (Lexington, MA) for a site visit and discussion of collaborative work

 

May 2012
Congratulations to Guanbo Wang, who was awarded a highly competitive University Graduate School Fellowship for UMass-Amherst for the academic year 2012/2013


Dr. Cedric Bobst, Shunhai Wang, Guanbo Wang, and Hanwei Zhao went to Vancouver to attend the annual conference of the American Society for Mass Spectrometry and present their research
Prof. Kaltashov was invited to attend a Protein Engineering Summit in Boston (PEGS-2012), where he gave a presentation on new mass spectrometry-based approaches to study aggregation of protein drugs.


Several group members went to Biogen IDEC (Cambridge, MA) for a site visit and discussion of collaborative work

 

April 2012
The second edition of the textbook on mass spectrometry in biophysics (I.A. Kaltashov, S.J. Eyles. Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics and Interaction of Biomolecules, 2nd edition. New York: John Wiley & Sons, Inc., 2012 (ISBN 978-0-470-93779-2)) was published by J. Wiley and Sons – order your copy today!

 

March 2012

Congratulations to Dr. Rinat Abzalimov on becoming an Assistant Director of the Mass Spectrometry Center at UMass-Amherst


February 2012
A U.S. patent application was filed based on work by Guanbo Wang to develop new temperature-controlled ESI Ms source to study protein behavior under heat-stress conditions


January 2012
Two outstanding first-year graduate students have joined our research group: Jake Pawlowski (UMass-Amherst 2011) and Shengsheng Xu (Wuhan University 2011) 

Selected Publications

Link to all Publications

 

G. Wang and I.A. Kaltashov. A new approach to characterization of the higher order structure of disulfide-containing proteins using hydrogen/deuterium exchange and top-down mass spectrometry. Anal. Chem. 2014, 86, 7293-7298

See Article

 

I.A. Kaltashov, C.E. Bobst, S.N. Nguyen, S. Wang. Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriers. Adv. Drug Deliv. Rev., 2013, 65, 1020-1030

See Article

 

G. Wang, R.R. Abzalimov, C.E. Bobst, and I.A. Kaltashov. Conformer-specific characterization of non-native protein states with high spatial resolution using hydrogen exchange and top-down mass spectrometry. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 20087-20092
R.R. Abzalimov, C.E. Bobst, and I.A. Kaltashov. A new approach to measuring protein backbone protection with high spatial resolution using H/D exchange and electron capture dissociation. Anal. Chem. 2013, 85, 9173-9180 See Article

 

C.E. Bobst, S. Wang, W.-C. Shen, and I.A. Kaltashov. Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 13544-13548

See Article

 

S. Wang, and I.A. Kaltashov. A new strategy of using O18-labeled iodoacetic acid for mass spectrometry-based protein quantitation. J. Am. Soc. Mass Spectrom. 2012, 23, 1293-1297

See Article


I.A. Kaltashov, C.E. Bobst, R.R. Abzalimov, G. Wang, B. Baykal, S. Wang. Advances and challenges in analytical characterization of biotechnology products: Mass spectrometry-based approaches to study properties and behavior of protein therapeutics. Biotechnol. Adv., 2012, 30, 210-222

See Article

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Collaborators

Professor Anne B. Mason

University of Vermont College of Medicine (Burlington, VT)

 

Biogen IDEC

Cambridge, MA

 

Bruker Daltonics

Billerica, MA

 

Shire Human Genetics Therapies

Cambridge, MA

 

Professor Wei-Chiang Shen

University of Southern California (Los Angeles, CA)