About Us

 

We are a Biological Mass Spectrometry group at the University of Massachusetts Amherst. Our research is focused on developing mass spectrometry-based strategies to study protein architecture, dynamics, and interactions with small molecules and other biopolymers.

 

Contact Our Lab

 

Address:

University of Masschusetts Department of Chemistry

710 North Pleasant Street, LGRT #104

Amherst, MA 01003

Telephone:

Lab: 413.545.4888
Professor Kaltashov's Office: 413.545.1460

Email:

Kaltashov@chem.umass.edu

 

 

Our laboratory is located in Goessmann Building, Room 267, on 686 North Pleasant Street.


Recent News

 

June 2012
Several group members went to Shire Human Genetic Therapies (Lexington, MA) for a site visit and discussion of collaborative work

 

May 2012
Congratulations to Guanbo Wang, who was awarded a highly competitive University Graduate School Fellowship for UMass-Amherst for the academic year 2012/2013


Dr. Cedric Bobst, Shunhai Wang, Guanbo Wang, and Hanwei Zhao went to Vancouver to attend the annual conference of the American Society for Mass Spectrometry and present their research
Prof. Kaltashov was invited to attend a Protein Engineering Summit in Boston (PEGS-2012), where he gave a presentation on new mass spectrometry-based approaches to study aggregation of protein drugs.


Several group members went to Biogen IDEC (Cambridge, MA) for a site visit and discussion of collaborative work

 

April 2012
The second edition of the textbook on mass spectrometry in biophysics (I.A. Kaltashov, S.J. Eyles. Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics and Interaction of Biomolecules, 2nd edition. New York: John Wiley & Sons, Inc., 2012 (ISBN 978-0-470-93779-2)) was published by J. Wiley and Sons – order your copy today!

 

March 2012

Congratulations to Dr. Rinat Abzalimov on becoming an Assistant Director of the Mass Spectrometry Center at UMass-Amherst


February 2012
A U.S. patent application was filed based on work by Guanbo Wang to develop new temperature-controlled ESI Ms source to study protein behavior under heat-stress conditions


January 2012
Two outstanding first-year graduate students have joined our research group: Jake Pawlowski (UMass-Amherst 2011) and Shengsheng Xu (Wuhan University 2011) 

Recent Publications

  1. S. Wang, and I.A. Kaltashov. A new strategy of using O18-labeled iodoacetic acid for mass spectrometry-based protein quantitation. J. Am. Soc. Mass Spectrom. 2012, 23, 1293-1297
  2. G. Wang, A.J. Johnson, I.A. Kaltashov. Evaluation of Electrospray Ionization Mass Spectrometry as a Tool for Characterization of Small Soluble Protein Aggregates. Anal. Chem. 2012, 84, 1718-1724
  3. I.A. Kaltashov, C.E. Bobst, M. Zhang, R. Leverence, D.R. Gumerov. Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry. Biophys. Biochim. Acta, 2012, 1820, 417-426
  4. I.A. Kaltashov, C.E. Bobst, R.R. Abzalimov, G. Wang, B. Baykal, S. Wang. Advances and challenges in analytical characterization of biotechnology products: Mass spectrometry-based approaches to study properties and behavior of protein therapeutics. Biotechnol. Adv., 2012, 30, 210-222
  5. Guanbo Wang, Rinat R. Abzalimov, and Igor A. Kaltashov. Direct Monitoring of Heat-Stressed Biopolymers with Temperature-Controlled Electrospray Ionization Mass Spectrometry. Anal. Chem., 2011, 83(8), 2870-2876
  6. R. Leverence, A.B. Mason, I.A. Kaltashov, Non-canonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 8123-8128
  7. I.A. Kaltashov, C.E. Bobst, R.R. Abzalimov, S.A. Berkowitz, D. Houde. Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry. J. Am. Soc. Mass Spectrom. 2010, 21, 323-337

 

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Collaborators

Professor Anne B. Mason

University of Vermont College of Medicine (Burlington, VT)

 

Biogen IDEC

Cambridge, MA

 

Bruker Daltonics

Billerica, MA

 

Shire Human Genetics Therapies

Cambridge, MA

 

Professor Wei-Chiang Shen

University of Southern California (Los Angeles, CA)