CHEM 777 Spring 2003 TTh 1:00-2:15, LGRT 321
http://www.chem.umass.edu/~thompson/Courses/Chem777/Spring03/
Nuclear Magnetic Resonance: Principles and Biological Applications
This course will introduce the basic principles of NMR, provide a survey of the major techniques and how they work, and illustrate the types of information which can be gained, particularly about macromolecules. It should be of interest to senior undergraduates and graduate students with interests in chemistry, biochemistry, or polymer science.
Instructor: Lynmarie Thompson
thompson@chem.umass.edu
Office: 403E, Phone: 5-0827, Mailbox: LGRT 713C
Text: Biomolecular NMR Spectroscopy, by Jeremy Evans
Errata - pdf file
NMR Bibliography (including books on reserve) - pdf file
Prerequisite: junior level physical chemistry course
Course requirements:
Homework/discussions, 3 Exams, Presentation - grading is 20% each
Homework/discussions: In order to foster interactive class discussions, the primary homework assignment will be to do the assigned reading BEFORE class. To encourage this habit, a discussion grade will be based on your ability to answer in-class questions, and your participation (contributing questions & discussion). Discussions of assigned homework problems are encouraged, but you must understand what you turn in.
Exams: take-home, open-book & notes, discussions prohibited
Presentation: 30 minute class presentation of a recent NMR application or technique. Choose a topic and get instructor's approval. At the class before your scheduled presentation, provide copies of one reference. Explain the NMR techniques as needed and how they address important questions about the system. Turn in a possible final exam question + answer on your topic.
Topic ideas (specific papers within areas such as these):
H exchange studies of protein folding
NMR studies of protein dynamics -- relaxation analyses
Transferred NOE -- ligands bound to large proteins
Nucleic acid structure determination
NMR of quadrupolar nuclei -- protein dynamics
Introductions
Please send me an email message by next Monday 2/3 which includes the following:
Name, Major & research group
NMR background/experience
NMR interest -- what topics you'd like to see in this course