Welcome to the Chen Research Group!

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Contact Us

Lab: 820 LGRT
phone: +1-413-547-3390

Office: 865 LGRT
phone: +1-413-545-0683

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Research Overview

Research in the Chen group focuses on membrane proteins, specifically pore-forming proteins (PFP). We aim to understand the folding, assembly, dynamics and functional mechanism of PFPs. In parallel, we use what we learn about PFPs to develop biotechnological applications for sensing disease markers and treating cancer. To achieve our goal, the research in Chen’s lab uses a combination of approaches in molecular biology, biochemistry and biophysics.

Areas of Our Research

1. The non-classic attack pathway of E. coli ClyA pore-forming toxin

2. An OmpG nanopore tool kit for sensing disease markers

3. Molecular translocation through nanopores